This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EHD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EHD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EHD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:47,427,132–47,428,809 | 286.2 kb | Distal (>10kb) Multiome HiCAR | 506 | |
| chr19:47,429,865–47,430,531 | 283.1 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr19:47,447,043–47,448,262 | 265.8 kb | Distal (>10kb) Multiome HiCAR | 510 | |
| chr19:47,471,631–47,472,340 | 241.4 kb | Distal (>10kb) Multiome HiCAR | 500 | |
| chr19:47,483,636–47,484,543 | 229.2 kb | Distal (>10kb) Multiome HiCAR | 841 | |
| chr19:47,514,152–47,515,901 | 198.1 kb | Distal (>10kb) Multiome HiCAR | 895 | |
| chr19:47,600,223–47,600,983 | 112.9 kb | Distal (>10kb) Multiome | 807 | |
| chr19:47,607,980–47,609,479 | 104.6 kb | Distal (>10kb) Multiome | 832 | |
| chr19:47,647,803–47,648,987 | 65.0 kb | Distal (>10kb) Multiome | 693 | |
| chr19:47,707,370–47,707,591 | 5.8 kb | Proximal (<10kb) | 370 | |
| chr19:47,713,217–47,713,638 | at TSS | At TSS | 428 | |
| chr19:47,729,949–47,730,505 | 16.8 kb | Distal (>10kb) Multiome | 425 | |
| chr19:47,743,369–47,743,911 | 30.3 kb | Distal (>10kb) Multiome | 929 | |
| chr19:47,745,136–47,745,915 | 32.2 kb | Distal (>10kb) Multiome | 784 | |
| chr19:47,765,762–47,766,380 | 52.6 kb | Distal (>10kb) Multiome | 296 | |
| chr19:47,770,120–47,770,789 | 57.0 kb | Distal (>10kb) Multiome | 127 | |
| chr19:47,778,102–47,779,241 | 65.1 kb | Distal (>10kb) Multiome | 845 | |
| chr19:47,788,509–47,789,220 | 75.3 kb | Distal (>10kb) Multiome | 365 | |
| chr19:47,790,277–47,790,794 | 77.1 kb | Distal (>10kb) Multiome | 275 | |
| chr19:47,848,678–47,850,092 | 136.5 kb | Distal (>10kb) Multiome | 398 | |
| chr19:47,863,487–47,864,048 | 150.3 kb | Distal (>10kb) Multiome | 384 | |
| chr19:47,891,593–47,892,745 | 178.9 kb | Distal (>10kb) Multiome | 522 |
Genomic view of the EHD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.