Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in actin cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EFR3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFR3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFR3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:24,792,642–24,794,076 | 248.8 kb | Distal (>10kb) Multiome | 1010 | |
| chr2:24,821,671–24,822,465 | 219.9 kb | Distal (>10kb) Multiome | 172 | |
| chr2:24,827,474–24,828,282 | 214.3 kb | Distal (>10kb) Multiome | 460 | |
| chr2:24,919,504–24,920,824 | 121.9 kb | Distal (>10kb) Multiome | 431 | |
| chr2:24,971,247–24,972,384 | 70.2 kb | Distal (>10kb) Multiome | 1032 | |
| chr2:25,041,314–25,043,455 | 52 bp | At TSS Multiome | 743 | |
| chr2:25,131,383–25,132,709 | 90.2 kb | Distal (>10kb) Multiome | 162 | |
| chr2:25,161,156–25,161,629 | 119.3 kb | Distal (>10kb) Multiome | 112 | |
| chr2:25,168,208–25,168,958 | 126.5 kb | Distal (>10kb) Multiome | 225 | |
| chr2:25,215,506–25,216,577 | 174.0 kb | Distal (>10kb) Multiome | 303 | |
| chr2:25,228,812–25,229,707 | 186.9 kb | Distal (>10kb) Multiome | 332 | |
| chr2:25,250,582–25,253,280 | 210.3 kb | Distal (>10kb) Multiome | 927 | |
| chr2:25,256,230–25,257,422 | 214.6 kb | Distal (>10kb) Multiome | 198 | |
| chr2:25,259,433–25,260,091 | 217.7 kb | Distal (>10kb) Multiome | 160 | |
| chr2:25,276,533–25,277,585 | 235.2 kb | Distal (>10kb) Multiome | 258 | |
| chr2:25,314,940–25,315,608 | 273.0 kb | Distal (>10kb) Multiome | 196 | |
| chr2:25,339,832–25,342,944 | 300.4 kb | Distal (>10kb) Multiome | 921 |
Genomic view of the EFR3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.