Enables cadherin binding activity. Predicted to be located in membrane raft. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EFHD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFHD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFHD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:15,139,767–15,140,647 | 269.9 kb | Distal (>10kb) Multiome | 554 | |
| chr1:15,152,399–15,154,344 | 256.1 kb | Distal (>10kb) Multiome | 772 | |
| chr1:15,196,898–15,197,476 | 212.7 kb | Distal (>10kb) Multiome | 173 | |
| chr1:15,246,891–15,247,752 | 162.6 kb | Distal (>10kb) Multiome | 362 | |
| chr1:15,403,140–15,403,419 | 6.5 kb | Proximal (<10kb) | 24 | |
| chr1:15,409,150–15,410,227 | 116 bp | At TSS Multiome | 618 | |
| chr1:15,412,068–15,412,674 | 2.4 kb | Proximal (<10kb) Multiome | 120 | |
| chr1:15,523,864–15,525,570 | 114.8 kb | Distal (>10kb) Multiome | 674 | |
| chr1:15,526,118–15,527,442 | 116.9 kb | Distal (>10kb) Multiome | 899 | |
| chr1:15,584,405–15,585,197 | 174.9 kb | Distal (>10kb) Multiome | 693 | |
| chr1:15,603,163–15,603,936 | 193.7 kb | Distal (>10kb) Multiome | 795 | |
| chr1:15,616,785–15,618,260 | 207.5 kb | Distal (>10kb) Multiome | 909 | |
| chr1:15,676,618–15,677,408 | 267.3 kb | Distal (>10kb) Multiome | 95 |
Genomic view of the EFHD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.