Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EFCAB5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFCAB5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFCAB5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:29,761,028–29,761,644 | 168.5 kb | Distal (>10kb) Multiome | 643 | |
| chr17:29,929,376–29,930,689 | 192 bp | At TSS Multiome | 768 | |
| chr17:29,930,801–29,930,957 | 899 bp | At TSS | 86 | |
| chr17:30,116,470–30,117,077 | 186.9 kb | Distal (>10kb) Multiome | 800 |
Genomic view of the EFCAB5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.