The gene encodes a protein that contains two EF-hand calcium-binding domains although its function has yet to be determined. Alternatively spliced transcripts have been observed. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for EFCAB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFCAB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFCAB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:244,730,143–244,731,325 | 239.6 kb | Distal (>10kb) Multiome | 295 | |
| chr1:244,815,498–244,816,101 | 154.6 kb | Distal (>10kb) Multiome | 177 | |
| chr1:244,833,808–244,836,513 | 135.0 kb | Distal (>10kb) Multiome | 1226 | |
| chr1:244,862,633–244,865,438 | 105.7 kb | Distal (>10kb) Multiome | 1124 | |
| chr1:244,968,324–244,968,761 | 1.6 kb | Proximal (<10kb) | 68 | |
| chr1:244,969,529–244,971,459 | 325 bp | At TSS Multiome | 1136 | |
| chr1:245,051,083–245,052,207 | 81.4 kb | Distal (>10kb) Multiome | 353 | |
| chr1:245,093,040–245,095,301 | 124.0 kb | Distal (>10kb) Multiome | 322 | |
| chr1:245,153,093–245,157,406 | 186.3 kb | Distal (>10kb) Multiome | 719 | |
| chr1:245,244,768–245,245,602 | 275.0 kb | Distal (>10kb) Multiome | 190 |
Genomic view of the EFCAB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.