Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EEF2KMT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEF2KMT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEF2KMT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,801,836–4,803,175 | 295.0 kb | Distal (>10kb) Multiome | 743 | |
| chr16:4,846,559–4,848,209 | 250.4 kb | Distal (>10kb) Multiome | 803 | |
| chr16:4,936,143–4,937,673 | 160.5 kb | Distal (>10kb) Multiome | 655 | |
| chr16:4,943,173–4,943,813 | 154.4 kb | Distal (>10kb) Multiome | 609 | |
| chr16:4,957,489–4,958,782 | 139.6 kb | Distal (>10kb) Multiome | 802 | |
| chr16:5,033,461–5,034,081 | 63.9 kb | Distal (>10kb) Multiome | 932 | |
| chr16:5,071,693–5,072,259 | 25.9 kb | Distal (>10kb) Multiome | 940 | |
| chr16:5,092,322–5,092,569 | 5.2 kb | Proximal (<10kb) | 202 | |
| chr16:5,097,069–5,098,979 | 304 bp | At TSS Multiome | 638 | |
| chr16:5,239,557–5,240,083 | 142.0 kb | Distal (>10kb) Multiome | 57 |
Genomic view of the EEF2KMT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.