The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EDIL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EDIL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EDIL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:83,714,660–83,715,756 | 669.3 kb | Distal (>10kb) Multiome HiCAR | 275 | |
| chr5:84,377,151–84,377,395 | 7.0 kb | Proximal (<10kb) | 9 | |
| chr5:84,381,925–84,385,527 | 395 bp | At TSS Multiome | 606 | |
| chr5:84,480,888–84,481,719 | 96.8 kb | Distal (>10kb) Multiome | 161 |
Genomic view of the EDIL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.