Predicted to enable lyase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ECHDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ECHDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ECHDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:52,632,811–52,633,791 | 288.2 kb | Distal (>10kb) Multiome | 269 | |
| chr1:52,662,669–52,663,405 | 258.4 kb | Distal (>10kb) Multiome | 285 | |
| chr1:52,697,629–52,698,936 | 223.1 kb | Distal (>10kb) Multiome | 997 | |
| chr1:52,702,879–52,703,689 | 218.4 kb | Distal (>10kb) Multiome | 872 | |
| chr1:52,726,263–52,726,954 | 195.0 kb | Distal (>10kb) Multiome | 681 | |
| chr1:52,842,499–52,843,778 | 78.7 kb | Distal (>10kb) Multiome | 687 | |
| chr1:52,904,762–52,905,209 | at TSS | At TSS | 231 | |
| chr1:52,921,024–52,921,900 | 93 bp | At TSS Multiome | 693 | |
| chr1:52,926,942–52,927,992 | 5.8 kb | Proximal (<10kb) Multiome | 610 | |
| chr1:53,062,171–53,063,328 | 141.6 kb | Distal (>10kb) Multiome | 134 | |
| chr1:53,115,329–53,116,462 | 194.5 kb | Distal (>10kb) Multiome | 396 | |
| chr1:53,196,600–53,197,254 | 275.3 kb | Distal (>10kb) Multiome | 711 | |
| chr1:53,220,162–53,220,983 | 299.0 kb | Distal (>10kb) Multiome | 1003 |
Genomic view of the ECHDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.