Enables transcription elongation factor activity. Involved in regulation of transcription elongation by RNA polymerase II. Located in intercellular bridge and nuclear body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:15,305,253–15,306,068 | 121.9 kb | Distal (>10kb) Multiome | 367 | |
| chr3:15,331,772–15,333,155 | 94.9 kb | Distal (>10kb) Multiome | 642 | |
| chr3:15,356,271–15,357,033 | 70.9 kb | Distal (>10kb) Multiome | 98 | |
| chr3:15,377,980–15,378,549 | 49.2 kb | Distal (>10kb) Multiome | 575 | |
| chr3:15,427,190–15,427,854 | 101 bp | At TSS Multiome | 758 |
Genomic view of the EAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.