Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. This gene encodes a subunit of the human cytoplasmic dynein-2 complex. Mutations in this gene are associated with short-rib thoracic dysplasia 17 with or without polydactyly. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for DYNLT2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNLT2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNLT2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:196,081,045–196,082,675 | 236.2 kb | Distal (>10kb) Multiome | 1081 | |
| chr3:196,110,410–196,110,962 | 207.7 kb | Distal (>10kb) Multiome | 307 | |
| chr3:196,207,804–196,208,801 | 110.1 kb | Distal (>10kb) Multiome | 300 | |
| chr3:196,273,588–196,274,153 | 44.5 kb | Distal (>10kb) Multiome | 95 | |
| chr3:196,287,125–196,288,362 | 30.5 kb | Distal (>10kb) Multiome | 979 | |
| chr3:196,317,553–196,318,672 | 88 bp | At TSS Multiome | 830 | |
| chr3:196,431,516–196,433,176 | 114.2 kb | Distal (>10kb) Multiome | 851 | |
| chr3:196,503,288–196,504,272 | 185.5 kb | Distal (>10kb) Multiome | 897 | |
| chr3:196,528,585–196,529,088 | 210.6 kb | Distal (>10kb) Multiome | 425 | |
| chr3:196,568,218–196,569,450 | 250.4 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the DYNLT2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.