This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for DYNLRB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNLRB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNLRB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,302,649–34,303,619 | 213.2 kb | Distal (>10kb) Multiome HiCAR | 1055 | |
| chr20:34,311,332–34,311,914 | 204.9 kb | Distal (>10kb) Multiome HiCAR | 577 | |
| chr20:34,312,547–34,313,008 | 203.6 kb | Distal (>10kb) Multiome HiCAR | 740 | |
| chr20:34,345,865–34,346,371 | 170.3 kb | Distal (>10kb) Multiome | 61 | |
| chr20:34,362,888–34,363,977 | 153.2 kb | Distal (>10kb) Multiome | 858 | |
| chr20:34,515,293–34,516,855 | 912 bp | At TSS Multiome | 1003 | |
| chr20:34,549,322–34,549,906 | 33.3 kb | Distal (>10kb) Multiome | 216 | |
| chr20:34,558,287–34,559,412 | 42.3 kb | Distal (>10kb) Multiome | 380 | |
| chr20:34,676,509–34,677,593 | 160.6 kb | Distal (>10kb) Multiome | 954 | |
| chr20:34,703,810–34,705,103 | 188.1 kb | Distal (>10kb) Multiome | 903 | |
| chr20:34,708,877–34,710,404 | 193.3 kb | Distal (>10kb) Multiome | 576 |
Genomic view of the DYNLRB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.