Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based process. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DYNLL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNLL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNLL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:57,783,050–57,783,717 | 300.0 kb | Distal (>10kb) Multiome | 468 | |
| chr17:57,833,107–57,833,593 | 250.2 kb | Distal (>10kb) Multiome HiCAR | 406 | |
| chr17:57,849,786–57,850,720 | 233.3 kb | Distal (>10kb) Multiome HiCAR | 1079 | |
| chr17:57,851,171–57,852,883 | 230.9 kb | Distal (>10kb) Multiome HiCAR | 649 | |
| chr17:57,860,878–57,862,423 | 222.1 kb | Distal (>10kb) Multiome HiCAR | 875 | |
| chr17:57,868,191–57,868,869 | 214.8 kb | Distal (>10kb) Multiome HiCAR | 587 | |
| chr17:57,874,428–57,875,544 | 208.6 kb | Distal (>10kb) Multiome HiCAR | 639 | |
| chr17:57,892,543–57,893,376 | 190.7 kb | Distal (>10kb) Multiome HiCAR | 825 | |
| chr17:57,901,269–57,901,796 | 181.8 kb | Distal (>10kb) Multiome | 289 | |
| chr17:57,926,939–57,927,538 | 156.2 kb | Distal (>10kb) Multiome | 259 | |
| chr17:57,954,427–57,955,892 | 128.0 kb | Distal (>10kb) Multiome | 612 | |
| chr17:57,987,092–57,989,001 | 95.1 kb | Distal (>10kb) Multiome | 1036 | |
| chr17:58,006,337–58,008,268 | 75.9 kb | Distal (>10kb) Multiome HiCAR | 1147 | |
| chr17:58,082,555–58,084,952 | 110 bp | At TSS Multiome | 835 | |
| chr17:58,156,945–58,157,756 | 73.8 kb | Distal (>10kb) Multiome | 235 | |
| chr17:58,218,800–58,219,654 | 135.9 kb | Distal (>10kb) Multiome | 890 | |
| chr17:58,249,147–58,250,121 | 166.3 kb | Distal (>10kb) Multiome | 737 | |
| chr17:58,324,153–58,325,169 | 241.1 kb | Distal (>10kb) Multiome | 274 | |
| chr17:58,338,012–58,338,430 | 254.8 kb | Distal (>10kb) Multiome | 559 | |
| chr17:58,339,009–58,339,515 | 255.9 kb | Distal (>10kb) Multiome | 382 | |
| chr17:58,351,751–58,352,762 | 268.9 kb | Distal (>10kb) Multiome | 990 |
Genomic view of the DYNLL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.