Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for DYNC1LI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNC1LI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNC1LI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:66,549,337–66,550,427 | 201.7 kb | Distal (>10kb) Multiome | 817 | |
| chr16:66,552,056–66,553,030 | 199.0 kb | Distal (>10kb) Multiome | 994 | |
| chr16:66,603,736–66,605,778 | 146.9 kb | Distal (>10kb) Multiome | 907 | |
| chr16:66,608,358–66,609,044 | 142.9 kb | Distal (>10kb) Multiome | 698 | |
| chr16:66,616,501–66,617,327 | 134.7 kb | Distal (>10kb) Multiome | 204 | |
| chr16:66,695,775–66,697,411 | 54.7 kb | Distal (>10kb) Multiome | 714 | |
| chr16:66,751,110–66,752,176 | 185 bp | At TSS Multiome | 734 | |
| chr16:66,830,425–66,831,324 | 79.3 kb | Distal (>10kb) Multiome | 934 | |
| chr16:66,844,097–66,844,861 | 92.8 kb | Distal (>10kb) Multiome | 211 | |
| chr16:66,872,965–66,873,714 | 121.7 kb | Distal (>10kb) Multiome | 836 | |
| chr16:66,880,003–66,881,270 | 128.9 kb | Distal (>10kb) Multiome | 1020 | |
| chr16:66,924,739–66,925,515 | 173.5 kb | Distal (>10kb) Multiome | 395 | |
| chr16:66,933,957–66,934,849 | 182.8 kb | Distal (>10kb) Multiome | 931 | |
| chr16:67,000,412–67,001,423 | 249.4 kb | Distal (>10kb) Multiome | 270 | |
| chr16:67,013,778–67,014,584 | 262.5 kb | Distal (>10kb) Multiome | 594 | |
| chr16:67,017,916–67,018,379 | 266.5 kb | Distal (>10kb) Multiome | 530 | |
| chr16:67,028,567–67,029,938 | 277.5 kb | Distal (>10kb) Multiome | 1003 |
Genomic view of the DYNC1LI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.