The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for DYNC1LI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNC1LI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNC1LI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:32,391,537–32,392,862 | 178.9 kb | Distal (>10kb) Multiome | 743 | |
| chr3:32,401,271–32,402,070 | 169.1 kb | Distal (>10kb) Multiome | 697 | |
| chr3:32,410,258–32,411,225 | 160.0 kb | Distal (>10kb) Multiome | 187 | |
| chr3:32,459,983–32,460,759 | 110.5 kb | Distal (>10kb) Multiome | 287 | |
| chr3:32,467,571–32,468,117 | 102.9 kb | Distal (>10kb) Multiome | 389 | |
| chr3:32,502,116–32,503,121 | 68.2 kb | Distal (>10kb) Multiome | 723 | |
| chr3:32,569,852–32,571,425 | 85 bp | At TSS Multiome | 915 | |
| chr3:32,571,924–32,572,353 | 1.1 kb | Proximal (<10kb) | 32 | |
| chr3:32,573,813–32,574,374 | 3.0 kb | Proximal (<10kb) | 15 | |
| chr3:32,603,070–32,603,802 | 32.5 kb | Distal (>10kb) Multiome | 180 | |
| chr3:32,643,387–32,643,863 | 72.8 kb | Distal (>10kb) Multiome HiCAR | 118 | |
| chr3:32,684,803–32,685,731 | 114.4 kb | Distal (>10kb) Multiome | 954 | |
| chr3:32,780,031–32,781,873 | 210.2 kb | Distal (>10kb) Multiome | 958 | |
| chr3:32,815,741–32,817,565 | 245.8 kb | Distal (>10kb) Multiome | 713 | |
| chr3:32,842,816–32,844,607 | 272.8 kb | Distal (>10kb) Multiome | 404 | |
| chr3:32,869,123–32,870,147 | 299.0 kb | Distal (>10kb) Multiome | 264 |
Genomic view of the DYNC1LI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.