DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DVL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DVL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DVL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,058,856–1,060,114 | 289.9 kb | Distal (>10kb) Multiome | 609 | |
| chr1:1,068,556–1,069,991 | 280.2 kb | Distal (>10kb) Multiome | 577 | |
| chr1:1,079,478–1,080,558 | 269.4 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 233.2 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 191.8 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,200,907–1,201,739 | 148.0 kb | Distal (>10kb) Multiome | 430 | |
| chr1:1,231,448–1,233,390 | 117.3 kb | Distal (>10kb) Multiome | 884 | |
| chr1:1,273,333–1,274,645 | 75.5 kb | Distal (>10kb) Multiome | 779 | |
| chr1:1,293,434–1,294,454 | 55.5 kb | Distal (>10kb) Multiome | 234 | |
| chr1:1,307,375–1,310,219 | 41.1 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,324,278–1,325,394 | 24.6 kb | Distal (>10kb) Multiome | 735 | |
| chr1:1,347,999–1,348,446 | 971 bp | At TSS | 457 | |
| chr1:1,348,716–1,350,027 | 124 bp | At TSS Multiome | 539 | |
| chr1:1,351,580–1,352,261 | 2.2 kb | Proximal (<10kb) | 194 | |
| chr1:1,353,403–1,354,425 | 4.5 kb | Proximal (<10kb) Multiome | 276 | |
| chr1:1,355,021–1,355,720 | 5.6 kb | Proximal (<10kb) | 184 | |
| chr1:1,358,274–1,359,049 | 8.9 kb | Proximal (<10kb) | 459 | |
| chr1:1,374,767–1,375,798 | 26.0 kb | Distal (>10kb) Multiome | 1113 | |
| chr1:1,398,861–1,399,955 | 50.0 kb | Distal (>10kb) Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 57.9 kb | Distal (>10kb) Multiome | 938 | |
| chr1:1,435,318–1,436,066 | 86.2 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 162.6 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 191.2 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 225.4 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 250.6 kb | Distal (>10kb) Multiome | 307 | |
| chr1:1,615,103–1,616,799 | 266.1 kb | Distal (>10kb) Multiome | 951 | |
| chr1:1,628,379–1,632,529 | 280.7 kb | Distal (>10kb) Multiome | 552 |
Genomic view of the DVL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.