DUSP3
dual specificity phosphatase 3 | VHR

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

Member of: DE-4
Biological processes 50 terms
MAP kinase phosphatase activity (GO:0033549)MAP kinase phosphatase activity (GO:0033549)cellular response to epidermal growth factor stimulus (GO:0071364)cellular response to epidermal growth factor stimulus (GO:0071364)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeletal protein binding (GO:0008092)cytosol (GO:0005829)cytosol (GO:0005829)dephosphorylation (GO:0016311)immunological synapse (GO:0001772)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of JNK cascade (GO:0046329)negative regulation of JNK cascade (GO:0046329)negative regulation of JNK cascade (GO:0046329)negative regulation of MAPK cascade (GO:0043409)negative regulation of T cell activation (GO:0050868)negative regulation of T cell activation (GO:0050868)negative regulation of T cell receptor signaling pathway (GO:0050860)negative regulation of T cell receptor signaling pathway (GO:0050860)negative regulation of cell migration (GO:0030336)negative regulation of chemotaxis (GO:0050922)negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)negative regulation of signal transduction (GO:0009968)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)peptidyl-tyrosine dephosphorylation (GO:0035335)phosphatase activity (GO:0016791)positive regulation of focal adhesion disassembly (GO:0120183)positive regulation of mitotic cell cycle (GO:0045931)positive regulation of mitotic cell cycle (GO:0045931)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein serine/threonine phosphatase activity (GO:0004722)protein tyrosine kinase binding (GO:1990782)protein tyrosine phosphatase activity (GO:0004725)protein tyrosine phosphatase activity (GO:0004725)protein tyrosine phosphatase activity (GO:0004725)protein tyrosine phosphatase activity (GO:0004725)protein tyrosine/serine/threonine phosphatase activity (GO:0008138)protein tyrosine/serine/threonine phosphatase activity (GO:0008138)protein tyrosine/serine/threonine phosphatase activity (GO:0008138)protein tyrosine/serine/threonine phosphatase activity (GO:0008138)receptor signaling protein tyrosine kinase inhibitor activity (GO:0030294)receptor tyrosine kinase binding (GO:0030971)regulation of focal adhesion assembly (GO:0051893)regulation of focal adhesion assembly (GO:0051893)
Expression (TPM)
DUSP3 — as a Regulated Gene

TFs regulating DUSP3 0 TFs

Transcription factors with Perturb-seq knockdown data for DUSP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUSP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to DUSP3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUSP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:43,483,594–43,484,268 294.5 kb Distal (>10kb) Multiome 1016
chr17:43,530,368–43,531,356 247.4 kb Distal (>10kb) Multiome HiCAR 828
chr17:43,545,066–43,547,010 232.7 kb Distal (>10kb) Multiome 999
chr17:43,694,216–43,694,699 83.8 kb Distal (>10kb) Multiome HiCAR 408
chr17:43,720,542–43,721,150 57.5 kb Distal (>10kb) Multiome 572
chr17:43,755,308–43,755,795 22.9 kb Distal (>10kb) Multiome 248
chr17:43,760,231–43,760,686 17.8 kb Distal (>10kb) Multiome 539
chr17:43,778,079–43,779,460 487 bp At TSS Multiome 937
chr17:43,832,658–43,833,385 54.9 kb Distal (>10kb) Multiome 455
chr17:43,900,207–43,900,990 122.3 kb Distal (>10kb) Multiome 308
chr17:43,906,025–43,906,856 128.3 kb Distal (>10kb) Multiome 353
chr17:43,907,081–43,907,899 129.4 kb Distal (>10kb) Multiome 362
chr17:43,937,932–43,938,382 159.9 kb Distal (>10kb) Multiome 757
chr17:43,952,298–43,953,752 174.7 kb Distal (>10kb) Multiome 295
chr17:43,983,489–43,984,364 205.7 kb Distal (>10kb) Multiome 743
chr17:44,004,236–44,007,875 226.4 kb Distal (>10kb) Multiome 807
chr17:44,014,255–44,015,168 236.6 kb Distal (>10kb) Multiome 1020
chr17:44,066,017–44,066,857 288.3 kb Distal (>10kb) Multiome 722
chr17:44,070,107–44,071,340 292.4 kb Distal (>10kb) Multiome 1041

Genome Browser

Genomic view of the DUSP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:43,473,594 – 44,081,340
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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