DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Transcription factors with Perturb-seq knockdown data for DTX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DTX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DTX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:76,163,449–76,164,544 | 297.7 kb | Distal (>10kb) Multiome | 132 | |
| chr7:76,166,338–76,167,166 | 295.0 kb | Distal (>10kb) Multiome | 644 | |
| chr7:76,177,965–76,178,641 | 283.4 kb | Distal (>10kb) Multiome | 670 | |
| chr7:76,201,356–76,202,307 | 259.9 kb | Distal (>10kb) Multiome | 937 | |
| chr7:76,234,695–76,235,681 | 226.4 kb | Distal (>10kb) Multiome | 329 | |
| chr7:76,259,707–76,261,052 | 201.3 kb | Distal (>10kb) Multiome | 332 | |
| chr7:76,267,044–76,267,853 | 194.3 kb | Distal (>10kb) Multiome | 211 | |
| chr7:76,282,299–76,283,220 | 179.0 kb | Distal (>10kb) Multiome | 237 | |
| chr7:76,291,428–76,292,275 | 169.8 kb | Distal (>10kb) Multiome | 767 | |
| chr7:76,302,207–76,304,173 | 159.2 kb | Distal (>10kb) Multiome | 943 | |
| chr7:76,314,028–76,314,686 | 147.3 kb | Distal (>10kb) Multiome | 715 | |
| chr7:76,317,523–76,319,173 | 143.5 kb | Distal (>10kb) Multiome | 840 | |
| chr7:76,358,237–76,359,989 | 102.4 kb | Distal (>10kb) Multiome | 1036 | |
| chr7:76,379,650–76,380,602 | 81.6 kb | Distal (>10kb) Multiome | 853 | |
| chr7:76,392,882–76,394,121 | 68.4 kb | Distal (>10kb) Multiome | 932 | |
| chr7:76,395,928–76,396,741 | 65.5 kb | Distal (>10kb) Multiome | 152 | |
| chr7:76,397,187–76,397,970 | 64.1 kb | Distal (>10kb) Multiome | 496 | |
| chr7:76,409,261–76,409,956 | 51.9 kb | Distal (>10kb) Multiome | 281 | |
| chr7:76,510,075–76,510,721 | 48.7 kb | Distal (>10kb) Multiome | 201 | |
| chr7:76,548,975–76,549,826 | 87.6 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the DTX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.