Enables Ala-tRNA(Thr) deacylase activity. Involved in aminoacyl-tRNA metabolism involved in translational fidelity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DTD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DTD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DTD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:31,206,827–31,208,656 | 249.6 kb | Distal (>10kb) Multiome | 1146 | |
| chr14:31,419,762–31,421,044 | 36.9 kb | Distal (>10kb) Multiome | 1119 | |
| chr14:31,456,819–31,457,870 | 85 bp | At TSS Multiome | 1008 | |
| chr14:31,458,186–31,458,795 | 698 bp | At TSS | 283 | |
| chr14:31,560,923–31,561,913 | 104.0 kb | Distal (>10kb) Multiome | 968 | |
| chr14:32,200,996–32,202,373 | 743.9 kb | Distal (>10kb) Multiome HiCAR | 951 | |
| chr14:32,202,830–32,204,312 | 746.0 kb | Distal (>10kb) Multiome HiCAR | 883 | |
| chr14:32,224,855–32,226,641 | 767.9 kb | Distal (>10kb) Multiome HiCAR | 350 |
Genomic view of the DTD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.