This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for DRG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DRG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DRG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:17,792,432–17,793,087 | 295.1 kb | Distal (>10kb) Multiome | 135 | |
| chr17:17,809,458–17,811,066 | 277.9 kb | Distal (>10kb) Multiome | 371 | |
| chr17:17,811,471–17,812,921 | 275.5 kb | Distal (>10kb) Multiome | 664 | |
| chr17:17,823,156–17,824,542 | 264.2 kb | Distal (>10kb) Multiome | 743 | |
| chr17:17,835,765–17,838,695 | 251.6 kb | Distal (>10kb) Multiome | 1030 | |
| chr17:17,839,788–17,841,046 | 247.7 kb | Distal (>10kb) Multiome | 927 | |
| chr17:17,921,363–17,921,988 | 166.3 kb | Distal (>10kb) Multiome | 341 | |
| chr17:17,943,271–17,943,954 | 144.4 kb | Distal (>10kb) Multiome | 143 | |
| chr17:17,971,984–17,973,164 | 115.3 kb | Distal (>10kb) Multiome | 716 | |
| chr17:18,035,659–18,036,594 | 51.9 kb | Distal (>10kb) Multiome | 186 | |
| chr17:18,038,656–18,040,279 | 48.7 kb | Distal (>10kb) Multiome | 839 | |
| chr17:18,087,629–18,088,063 | at TSS | At TSS | 1046 | |
| chr17:18,153,365–18,154,352 | 66.0 kb | Distal (>10kb) Multiome | 244 | |
| chr17:18,157,790–18,158,725 | 70.2 kb | Distal (>10kb) Multiome | 292 | |
| chr17:18,182,585–18,185,065 | 95.5 kb | Distal (>10kb) Multiome | 1051 | |
| chr17:18,224,148–18,226,173 | 136.7 kb | Distal (>10kb) Multiome | 680 | |
| chr17:18,246,777–18,247,912 | 159.3 kb | Distal (>10kb) Multiome | 314 | |
| chr17:18,257,865–18,259,083 | 170.7 kb | Distal (>10kb) Multiome | 684 | |
| chr17:18,260,145–18,261,582 | 172.7 kb | Distal (>10kb) Multiome | 778 | |
| chr17:18,314,513–18,315,715 | 227.2 kb | Distal (>10kb) Multiome | 865 | |
| chr17:18,363,090–18,363,830 | 275.6 kb | Distal (>10kb) Multiome | 760 |
Genomic view of the DRG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.