Transcription factors with Perturb-seq knockdown data for DRAIC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DRAIC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DRAIC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:69,452,178–69,453,528 | 9.4 kb | Proximal (<10kb) | 983 | |
| chr15:69,462,352–69,463,273 | at TSS | At TSS | 753 | |
| chr15:69,466,070–69,466,284 | 3.1 kb | Proximal (<10kb) | 245 | |
| chr15:69,467,703–69,468,077 | 4.8 kb | Proximal (<10kb) | 172 | |
| chr15:69,475,850–69,476,068 | 7.8 kb | Proximal (<10kb) | 207 | |
| chr15:69,552,979–69,553,564 | 4.5 kb | Proximal (<10kb) | 56 | |
| chr15:69,554,171–69,555,109 | 3.0 kb | Proximal (<10kb) | 267 | |
| chr15:69,555,386–69,555,733 | 2.3 kb | Proximal (<10kb) | 20 | |
| chr15:69,557,946–69,558,224 | at TSS | At TSS | 65 |
Genomic view of the DRAIC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.