This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for DPYSL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPYSL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPYSL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:26,692,280–26,693,600 | 155.4 kb | Distal (>10kb) Multiome | 275 | |
| chr2:26,749,944–26,750,505 | 98.0 kb | Distal (>10kb) Multiome | 322 | |
| chr2:26,764,126–26,764,575 | 83.8 kb | Distal (>10kb) Multiome | 781 | |
| chr2:26,785,402–26,786,601 | 62.2 kb | Distal (>10kb) Multiome | 996 | |
| chr2:26,846,388–26,846,855 | 1.6 kb | Proximal (<10kb) Multiome | 343 | |
| chr2:26,847,436–26,849,494 | 165 bp | At TSS Multiome | 447 | |
| chr2:26,961,589–26,962,066 | 113.8 kb | Distal (>10kb) Multiome | 502 | |
| chr2:26,970,294–26,971,331 | 122.4 kb | Distal (>10kb) Multiome | 572 | |
| chr2:27,032,577–27,033,271 | 184.8 kb | Distal (>10kb) Multiome | 799 | |
| chr2:27,049,564–27,052,299 | 203.4 kb | Distal (>10kb) Multiome | 1295 | |
| chr2:27,071,223–27,072,896 | 223.7 kb | Distal (>10kb) Multiome | 864 | |
| chr2:27,081,006–27,081,641 | 233.2 kb | Distal (>10kb) Multiome | 758 | |
| chr2:27,085,591–27,087,452 | 238.5 kb | Distal (>10kb) Multiome | 970 | |
| chr2:27,123,498–27,124,089 | 275.7 kb | Distal (>10kb) Multiome | 553 | |
| chr2:27,133,917–27,135,216 | 286.5 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the DPYSL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.