Enables filamin binding activity. Predicted to be involved in nervous system development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DPYSL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPYSL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPYSL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:131,899,878–131,901,850 | 286.2 kb | Distal (>10kb) Multiome | 732 | |
| chr10:131,929,125–131,929,784 | 257.5 kb | Distal (>10kb) Multiome | 62 | |
| chr10:131,981,341–131,982,864 | 204.9 kb | Distal (>10kb) Multiome | 815 | |
| chr10:131,998,677–131,999,655 | 187.7 kb | Distal (>10kb) Multiome | 271 | |
| chr10:132,001,275–132,002,395 | 185.3 kb | Distal (>10kb) Multiome | 161 | |
| chr10:132,002,510–132,004,411 | 183.4 kb | Distal (>10kb) Multiome | 240 | |
| chr10:132,035,668–132,037,081 | 150.3 kb | Distal (>10kb) Multiome | 214 | |
| chr10:132,112,772–132,114,093 | 73.6 kb | Distal (>10kb) Multiome | 141 | |
| chr10:132,163,327–132,163,783 | 23.4 kb | Distal (>10kb) Multiome | 240 | |
| chr10:132,185,497–132,188,136 | 1.3 kb | Proximal (<10kb) Multiome | 418 | |
| chr10:132,306,849–132,308,922 | 121.1 kb | Distal (>10kb) Multiome | 613 | |
| chr10:132,331,380–132,332,787 | 145.1 kb | Distal (>10kb) Multiome | 823 | |
| chr10:132,395,781–132,397,421 | 209.2 kb | Distal (>10kb) Multiome | 555 | |
| chr10:132,453,126–132,453,618 | 266.4 kb | Distal (>10kb) Multiome | 512 |
Genomic view of the DPYSL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.