Predicted to enable mannosyltransferase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DPY19L4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPY19L4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPY19L4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:94,436,616–94,437,535 | 282.7 kb | Distal (>10kb) Multiome | 334 | |
| chr8:94,474,579–94,475,673 | 244.7 kb | Distal (>10kb) Multiome | 722 | |
| chr8:94,553,030–94,554,248 | 166.1 kb | Distal (>10kb) Multiome | 938 | |
| chr8:94,605,142–94,605,744 | 114.2 kb | Distal (>10kb) Multiome | 82 | |
| chr8:94,638,867–94,642,864 | 80.4 kb | Distal (>10kb) Multiome | 705 | |
| chr8:94,709,859–94,710,135 | 9.6 kb | Proximal (<10kb) | 7 | |
| chr8:94,719,362–94,720,432 | 135 bp | At TSS Multiome | 1182 | |
| chr8:94,822,329–94,823,941 | 103.5 kb | Distal (>10kb) Multiome | 818 | |
| chr8:94,894,252–94,897,051 | 175.8 kb | Distal (>10kb) Multiome | 927 | |
| chr8:94,948,413–94,950,514 | 229.8 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the DPY19L4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.