This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for DPCD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPCD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPCD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:101,282,747–101,283,297 | 305.3 kb | Distal (>10kb) Multiome HiCAR | 74 | |
| chr10:101,285,534–101,286,046 | 302.4 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr10:101,288,327–101,289,007 | 299.7 kb | Distal (>10kb) Multiome HiCAR | 96 | |
| chr10:101,291,317–101,293,346 | 296.5 kb | Distal (>10kb) Multiome | 433 | |
| chr10:101,311,194–101,311,678 | 277.0 kb | Distal (>10kb) Multiome | 94 | |
| chr10:101,353,481–101,354,935 | 234.3 kb | Distal (>10kb) Multiome | 875 | |
| chr10:101,450,379–101,450,896 | 137.7 kb | Distal (>10kb) Multiome | 226 | |
| chr10:101,569,467–101,571,017 | 18.0 kb | Distal (>10kb) Multiome | 558 | |
| chr10:101,587,742–101,588,624 | 78 bp | At TSS Multiome | 673 | |
| chr10:101,597,095–101,597,276 | 8.8 kb | Proximal (<10kb) | 36 | |
| chr10:101,602,717–101,603,282 | 14.6 kb | Distal (>10kb) Multiome | 348 | |
| chr10:101,606,618–101,607,814 | 19.0 kb | Distal (>10kb) Multiome | 143 | |
| chr10:101,667,996–101,669,307 | 80.4 kb | Distal (>10kb) Multiome | 135 | |
| chr10:101,694,020–101,695,446 | 106.1 kb | Distal (>10kb) Multiome | 821 | |
| chr10:101,749,494–101,750,047 | 161.4 kb | Distal (>10kb) Multiome | 178 | |
| chr10:101,775,454–101,777,009 | 188.1 kb | Distal (>10kb) Multiome HiCAR | 202 | |
| chr10:101,778,233–101,781,743 | 192.9 kb | Distal (>10kb) Multiome HiCAR | 720 | |
| chr10:101,782,912–101,783,976 | 195.1 kb | Distal (>10kb) Multiome HiCAR | 661 | |
| chr10:101,817,350–101,819,352 | 230.3 kb | Distal (>10kb) Multiome | 1004 | |
| chr10:101,828,926–101,831,154 | 242.5 kb | Distal (>10kb) Multiome | 697 | |
| chr10:101,839,408–101,839,998 | 251.4 kb | Distal (>10kb) Multiome | 196 | |
| chr10:101,840,663–101,841,471 | 252.7 kb | Distal (>10kb) Multiome | 499 | |
| chr10:101,843,178–101,844,328 | 255.5 kb | Distal (>10kb) Multiome | 277 |
Genomic view of the DPCD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.