The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DPAGT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPAGT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPAGT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,907,074–118,907,685 | 194.6 kb | Distal (>10kb) Multiome | 491 | |
| chr11:118,909,181–118,909,816 | 192.5 kb | Distal (>10kb) Multiome | 326 | |
| chr11:118,909,976–118,911,609 | 191.2 kb | Distal (>10kb) Multiome | 652 | |
| chr11:118,911,717–118,912,963 | 189.6 kb | Distal (>10kb) Multiome | 689 | |
| chr11:118,916,429–118,917,335 | 184.9 kb | Distal (>10kb) Multiome | 355 | |
| chr11:118,917,640–118,918,851 | 183.4 kb | Distal (>10kb) Multiome | 522 | |
| chr11:118,925,703–118,926,356 | 175.8 kb | Distal (>10kb) Multiome | 595 | |
| chr11:118,927,947–118,930,852 | 172.4 kb | Distal (>10kb) Multiome | 892 | |
| chr11:118,997,538–118,998,797 | 103.8 kb | Distal (>10kb) Multiome | 798 | |
| chr11:119,018,081–119,019,265 | 83.3 kb | Distal (>10kb) Multiome | 897 | |
| chr11:119,029,885–119,031,330 | 70.9 kb | Distal (>10kb) Multiome | 876 | |
| chr11:119,056,436–119,057,778 | 44.6 kb | Distal (>10kb) Multiome | 815 | |
| chr11:119,067,446–119,068,100 | 34.1 kb | Distal (>10kb) Multiome | 762 | |
| chr11:119,084,563–119,085,756 | 16.8 kb | Distal (>10kb) Multiome | 846 | |
| chr11:119,093,969–119,096,070 | 6.3 kb | Proximal (<10kb) Multiome | 1046 | |
| chr11:119,101,351–119,102,791 | 274 bp | At TSS Multiome | 871 | |
| chr11:119,106,906–119,107,993 | 5.5 kb | Proximal (<10kb) Multiome | 650 | |
| chr11:119,120,857–119,122,037 | 19.6 kb | Distal (>10kb) Multiome | 787 | |
| chr11:119,144,795–119,145,355 | 43.2 kb | Distal (>10kb) Multiome | 230 | |
| chr11:119,148,816–119,149,933 | 47.7 kb | Distal (>10kb) Multiome | 262 | |
| chr11:119,168,601–119,169,645 | 67.1 kb | Distal (>10kb) Multiome | 794 | |
| chr11:119,205,241–119,207,150 | 104.3 kb | Distal (>10kb) Multiome | 695 | |
| chr11:119,315,017–119,315,819 | 213.5 kb | Distal (>10kb) Multiome HiCAR | 270 | |
| chr11:119,316,693–119,317,760 | 215.4 kb | Distal (>10kb) Multiome HiCAR | 463 | |
| chr11:119,320,617–119,321,906 | 219.9 kb | Distal (>10kb) Multiome | 516 | |
| chr11:119,334,140–119,334,815 | 232.5 kb | Distal (>10kb) Multiome HiCAR | 577 | |
| chr11:119,337,716–119,338,797 | 236.5 kb | Distal (>10kb) Multiome HiCAR | 412 | |
| chr11:119,339,587–119,340,902 | 238.3 kb | Distal (>10kb) Multiome HiCAR | 477 | |
| chr11:119,356,332–119,357,013 | 254.9 kb | Distal (>10kb) Multiome | 366 | |
| chr11:119,361,041–119,361,699 | 259.5 kb | Distal (>10kb) Multiome | 431 | |
| chr11:119,363,939–119,364,561 | 262.4 kb | Distal (>10kb) Multiome | 255 | |
| chr11:119,377,954–119,379,307 | 276.7 kb | Distal (>10kb) Multiome | 307 | |
| chr11:119,380,894–119,382,060 | 279.8 kb | Distal (>10kb) Multiome | 800 |
Genomic view of the DPAGT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.