A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for DOLPP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOLPP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOLPP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,786,928–128,787,516 | 293.9 kb | Distal (>10kb) Multiome | 1040 | |
| chr9:128,818,208–128,819,406 | 262.7 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,829,505–128,830,189 | 251.3 kb | Distal (>10kb) Multiome | 782 | |
| chr9:128,881,863–128,882,454 | 199.0 kb | Distal (>10kb) Multiome | 777 | |
| chr9:128,947,329–128,947,815 | 133.5 kb | Distal (>10kb) Multiome | 865 | |
| chr9:129,027,821–129,028,677 | 52.7 kb | Distal (>10kb) Multiome | 639 | |
| chr9:129,036,276–129,036,937 | 44.6 kb | Distal (>10kb) Multiome | 736 | |
| chr9:129,080,488–129,081,502 | 135 bp | At TSS Multiome | 755 | |
| chr9:129,110,314–129,111,708 | 29.9 kb | Distal (>10kb) Multiome | 881 | |
| chr9:129,177,207–129,178,809 | 97.2 kb | Distal (>10kb) Multiome | 824 | |
| chr9:129,208,459–129,208,914 | 127.6 kb | Distal (>10kb) Multiome | 108 | |
| chr9:129,334,082–129,334,794 | 253.3 kb | Distal (>10kb) Multiome | 928 |
Genomic view of the DOLPP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.