The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for DOLK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOLK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOLK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,656,436–128,657,126 | 290.8 kb | Distal (>10kb) Multiome | 1009 | |
| chr9:128,683,393–128,684,010 | 264.0 kb | Distal (>10kb) Multiome | 296 | |
| chr9:128,684,170–128,684,813 | 262.9 kb | Distal (>10kb) Multiome | 574 | |
| chr9:128,688,449–128,689,713 | 258.5 kb | Distal (>10kb) Multiome | 805 | |
| chr9:128,702,246–128,702,946 | 245.0 kb | Distal (>10kb) Multiome | 720 | |
| chr9:128,723,691–128,725,229 | 223.4 kb | Distal (>10kb) Multiome | 821 | |
| chr9:128,771,658–128,772,301 | 175.6 kb | Distal (>10kb) Multiome | 940 | |
| chr9:128,786,928–128,787,516 | 160.4 kb | Distal (>10kb) Multiome | 1040 | |
| chr9:128,818,208–128,819,406 | 129.2 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,829,505–128,830,189 | 117.8 kb | Distal (>10kb) Multiome | 782 | |
| chr9:128,881,863–128,882,454 | 65.5 kb | Distal (>10kb) Multiome | 777 | |
| chr9:128,921,941–128,922,727 | 25.3 kb | Distal (>10kb) Multiome | 378 | |
| chr9:128,947,329–128,947,815 | 32 bp | At TSS Multiome | 865 | |
| chr9:129,027,821–129,028,677 | 80.8 kb | Distal (>10kb) Multiome | 639 | |
| chr9:129,036,276–129,036,937 | 88.9 kb | Distal (>10kb) Multiome | 736 | |
| chr9:129,080,488–129,081,502 | 133.4 kb | Distal (>10kb) Multiome | 755 | |
| chr9:129,110,314–129,111,708 | 163.5 kb | Distal (>10kb) Multiome | 881 | |
| chr9:129,177,207–129,178,809 | 230.7 kb | Distal (>10kb) Multiome | 824 | |
| chr9:129,208,459–129,208,914 | 261.1 kb | Distal (>10kb) Multiome | 108 |
Genomic view of the DOLK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.