This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for DOCK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOCK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOCK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:50,435,932–50,436,533 | 238.7 kb | Distal (>10kb) Multiome | 248 | |
| chr3:50,502,505–50,504,160 | 171.2 kb | Distal (>10kb) Multiome | 312 | |
| chr3:50,567,311–50,568,123 | 107.2 kb | Distal (>10kb) Multiome | 376 | |
| chr3:50,568,824–50,569,934 | 105.6 kb | Distal (>10kb) Multiome | 901 | |
| chr3:50,611,315–50,612,530 | 63.0 kb | Distal (>10kb) Multiome | 904 | |
| chr3:50,615,997–50,617,867 | 57.8 kb | Distal (>10kb) Multiome | 754 | |
| chr3:50,674,463–50,675,603 | 237 bp | At TSS Multiome | 344 | |
| chr3:51,384,278–51,385,586 | 710.2 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr3:51,390,699–51,392,749 | 716.2 kb | Distal (>10kb) Multiome HiCAR | 824 |
Genomic view of the DOCK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.