Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of filopodium assembly. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DOCK11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOCK11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOCK11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:118,345,383–118,346,825 | 149.8 kb | Distal (>10kb) Multiome | 670 | |
| chrX:118,495,092–118,496,586 | 126 bp | At TSS Multiome | 565 | |
| chrX:118,499,418–118,499,907 | 3.6 kb | Proximal (<10kb) | 48 | |
| chrX:118,726,843–118,728,075 | 231.7 kb | Distal (>10kb) Multiome | 683 |
Genomic view of the DOCK11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.