DNTTIP1

deoxynucleotidyltransferase terminal interacting protein 1 | Tdif1, dJ447F3.4, C20orf167

DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]

Member of: DE-1

Biological processes 17 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)DNA binding (GO:0003677)chromatin organization (GO:0006325)chromosome (GO:0005694)histone deacetylase complex (GO:0000118)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleosome binding (GO:0031491)nucleosome binding (GO:0031491)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)regulation of embryonic development (GO:0045995)

Expression (TPM)

TFs regulating DNTTIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for DNTTIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNTTIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DNTTIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNTTIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:45,341,603–45,342,760	449.7 kb	Distal (>10kb) Multiome HiCAR	696
chr20:45,343,396–45,344,073	448.2 kb	Distal (>10kb) Multiome HiCAR	485
chr20:45,347,673–45,348,799	443.5 kb	Distal (>10kb) Multiome HiCAR	805
chr20:45,509,025–45,509,824	282.5 kb	Distal (>10kb) Multiome	109
chr20:45,764,655–45,765,666	26.9 kb	Distal (>10kb) Multiome	192
chr20:45,770,709–45,771,657	20.7 kb	Distal (>10kb) Multiome	436
chr20:45,791,633–45,792,259	10 bp	At TSS Multiome	882
chr20:45,812,087–45,813,052	20.5 kb	Distal (>10kb) Multiome	695
chr20:45,833,493–45,834,622	42.0 kb	Distal (>10kb) Multiome	833
chr20:45,856,871–45,858,137	65.6 kb	Distal (>10kb) Multiome	884
chr20:45,880,796–45,881,524	89.2 kb	Distal (>10kb) Multiome	738
chr20:45,890,127–45,891,800	99.4 kb	Distal (>10kb) Multiome	1095
chr20:45,910,538–45,912,397	120.3 kb	Distal (>10kb) Multiome	713
chr20:45,933,591–45,935,780	143.2 kb	Distal (>10kb) Multiome	1195
chr20:45,971,553–45,972,790	180.2 kb	Distal (>10kb) Multiome	1206
chr20:46,004,647–46,005,315	213.0 kb	Distal (>10kb) Multiome	207
chr20:46,011,604–46,012,166	220.0 kb	Distal (>10kb) Multiome	239
chr20:46,013,565–46,014,586	222.2 kb	Distal (>10kb) Multiome	735
chr20:46,021,209–46,023,166	230.0 kb	Distal (>10kb) Multiome	679
chr20:46,031,750–46,032,261	240.1 kb	Distal (>10kb) Multiome	227
chr20:46,058,408–46,058,983	266.8 kb	Distal (>10kb) Multiome	123
chr20:46,089,092–46,090,355	297.9 kb	Distal (>10kb) Multiome	1047
chr20:46,091,736–46,092,300	300.3 kb	Distal (>10kb) Multiome	38

Genome Browser

Genomic view of the DNTTIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.