This gene encodes a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for DNMBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNMBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNMBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:99,619,825–99,621,725 | 389.2 kb | Distal (>10kb) Multiome | 1070 | |
| chr10:99,658,847–99,660,052 | 350.6 kb | Distal (>10kb) Multiome | 728 | |
| chr10:99,731,799–99,732,929 | 277.7 kb | Distal (>10kb) Multiome | 941 | |
| chr10:99,913,671–99,914,615 | 95.9 kb | Distal (>10kb) Multiome | 256 | |
| chr10:99,918,086–99,918,341 | 4.0 kb | Proximal (<10kb) | 170 | |
| chr10:99,938,657–99,939,017 | 7.7 kb | Proximal (<10kb) | 136 | |
| chr10:100,009,381–100,010,564 | 5 bp | At TSS Multiome | 647 | |
| chr10:100,185,381–100,186,650 | 176.1 kb | Distal (>10kb) Multiome | 913 | |
| chr10:100,228,957–100,229,948 | 219.6 kb | Distal (>10kb) Multiome | 759 | |
| chr10:100,267,386–100,267,986 | 257.8 kb | Distal (>10kb) Multiome | 715 | |
| chr10:100,286,018–100,287,021 | 276.6 kb | Distal (>10kb) Multiome | 849 |
Genomic view of the DNMBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.