This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for DNM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:171,641,225–171,641,935 | 199.9 kb | Distal (>10kb) Multiome | 208 | |
| chr1:171,644,792–171,645,779 | 196.3 kb | Distal (>10kb) Multiome | 424 | |
| chr1:171,664,751–171,665,757 | 176.2 kb | Distal (>10kb) Multiome | 206 | |
| chr1:171,741,356–171,742,843 | 99.4 kb | Distal (>10kb) Multiome | 906 | |
| chr1:171,780,733–171,782,347 | 60.1 kb | Distal (>10kb) Multiome | 902 | |
| chr1:171,837,567–171,837,942 | 3.6 kb | Proximal (<10kb) | 3 | |
| chr1:171,840,670–171,842,693 | 111 bp | At TSS Multiome | 572 |
Genomic view of the DNM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.