Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for DNM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,417,499–10,421,409 | 297.8 kb | Distal (>10kb) Multiome | 801 | |
| chr19:10,424,198–10,424,839 | 293.6 kb | Distal (>10kb) Multiome | 563 | |
| chr19:10,431,990–10,432,435 | 285.9 kb | Distal (>10kb) Multiome | 301 | |
| chr19:10,460,915–10,461,960 | 256.7 kb | Distal (>10kb) Multiome | 340 | |
| chr19:10,502,251–10,503,615 | 215.3 kb | Distal (>10kb) Multiome | 1013 | |
| chr19:10,514,009–10,514,960 | 203.7 kb | Distal (>10kb) Multiome HiCAR | 172 | |
| chr19:10,517,347–10,518,104 | 200.3 kb | Distal (>10kb) Multiome HiCAR | 338 | |
| chr19:10,543,499–10,544,302 | 174.3 kb | Distal (>10kb) Multiome | 617 | |
| chr19:10,565,054–10,566,439 | 152.1 kb | Distal (>10kb) Multiome | 923 | |
| chr19:10,568,225–10,569,839 | 149.1 kb | Distal (>10kb) Multiome | 871 | |
| chr19:10,602,117–10,602,945 | 115.6 kb | Distal (>10kb) Multiome | 518 | |
| chr19:10,625,339–10,625,984 | 92.5 kb | Distal (>10kb) Multiome | 451 | |
| chr19:10,653,364–10,655,129 | 64.0 kb | Distal (>10kb) Multiome | 1086 | |
| chr19:10,695,264–10,696,403 | 22.2 kb | Distal (>10kb) Multiome | 831 | |
| chr19:10,701,273–10,702,291 | 16.6 kb | Distal (>10kb) Multiome | 889 | |
| chr19:10,717,121–10,718,717 | 326 bp | At TSS Multiome | 849 | |
| chr19:10,835,171–10,836,835 | 117.8 kb | Distal (>10kb) Multiome | 1096 | |
| chr19:10,870,403–10,872,620 | 153.1 kb | Distal (>10kb) Multiome | 714 | |
| chr19:10,928,331–10,929,395 | 210.6 kb | Distal (>10kb) Multiome | 860 | |
| chr19:10,960,232–10,961,863 | 242.8 kb | Distal (>10kb) Multiome | 1016 |
Genomic view of the DNM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.