This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for DNM1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNM1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNM1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:31,265,597–31,266,170 | 1413.3 kb | Distal (>10kb) Multiome HiCAR | 72 | |
| chr12:31,659,057–31,659,786 | 1020.0 kb | Distal (>10kb) Multiome HiCAR | 737 | |
| chr12:32,047,438–32,048,247 | 631.3 kb | Distal (>10kb) Multiome HiCAR | 272 | |
| chr12:32,398,922–32,400,774 | 279.7 kb | Distal (>10kb) Multiome HiCAR | 832 | |
| chr12:32,418,951–32,419,937 | 260.0 kb | Distal (>10kb) Multiome | 172 | |
| chr12:32,501,832–32,502,447 | 177.2 kb | Distal (>10kb) Multiome | 347 | |
| chr12:32,672,012–32,672,189 | 7.1 kb | Proximal (<10kb) | 215 | |
| chr12:32,678,963–32,680,020 | 10 bp | At TSS Multiome | 960 | |
| chr12:32,754,967–32,756,883 | 76.0 kb | Distal (>10kb) Multiome | 978 | |
| chr12:32,893,054–32,894,062 | 214.0 kb | Distal (>10kb) Multiome | 249 | |
| chr12:32,896,168–32,897,592 | 217.7 kb | Distal (>10kb) Multiome | 653 |
Genomic view of the DNM1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.