Predicted to enable Notch binding activity. Involved in central nervous system development. Located in dendrite; early endosome; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DNER. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNER upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNER, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:229,578,163–229,578,724 | 8.5 kb | Proximal (<10kb) | 51 | |
| chr2:229,586,554–229,587,834 | 44 bp | At TSS Multiome | 358 | |
| chr2:229,713,334–229,715,683 | 126.6 kb | Distal (>10kb) Multiome | 721 | |
| chr2:229,715,812–229,716,209 | 1.3 kb | Proximal (<10kb) | 104 | |
| chr2:229,921,112–229,923,271 | 335.1 kb | Distal (>10kb) Multiome | 1086 |
Genomic view of the DNER locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.