This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for DND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:140,400,395–140,402,925 | 272.0 kb | Distal (>10kb) Multiome | 1129 | |
| chr5:140,546,917–140,548,500 | 125.9 kb | Distal (>10kb) Multiome | 784 | |
| chr5:140,556,971–140,557,959 | 116.1 kb | Distal (>10kb) Multiome | 886 | |
| chr5:140,564,055–140,565,123 | 109.0 kb | Distal (>10kb) Multiome | 827 | |
| chr5:140,639,043–140,640,146 | 34.1 kb | Distal (>10kb) Multiome | 898 | |
| chr5:140,647,175–140,648,159 | 25.9 kb | Distal (>10kb) Multiome | 863 | |
| chr5:140,664,368–140,665,161 | 8.8 kb | Proximal (<10kb) Multiome | 856 | |
| chr5:140,672,392–140,672,986 | 589 bp | At TSS | 61 | |
| chr5:140,673,200–140,673,759 | 6 bp | At TSS Multiome | 144 | |
| chr5:140,691,053–140,691,933 | 17.9 kb | Distal (>10kb) Multiome | 924 | |
| chr5:140,699,981–140,700,742 | 26.8 kb | Distal (>10kb) Multiome | 607 | |
| chr5:140,710,433–140,711,671 | 37.6 kb | Distal (>10kb) Multiome | 856 | |
| chr5:140,925,961–140,927,592 | 253.0 kb | Distal (>10kb) Multiome | 419 | |
| chr5:140,965,919–140,967,712 | 293.0 kb | Distal (>10kb) Multiome | 368 |
Genomic view of the DND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.