This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DNALI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNALI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNALI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:37,473,950–37,475,117 | 82.4 kb | Distal (>10kb) Multiome | 695 | |
| chr1:37,513,871–37,515,291 | 42.1 kb | Distal (>10kb) Multiome | 884 | |
| chr1:37,553,845–37,554,497 | 2.6 kb | Proximal (<10kb) Multiome | 748 | |
| chr1:37,556,626–37,557,247 | 2 bp | At TSS Multiome | 284 | |
| chr1:37,595,631–37,596,377 | 39.1 kb | Distal (>10kb) Multiome | 754 | |
| chr1:37,634,598–37,635,064 | 77.9 kb | Distal (>10kb) Multiome | 192 | |
| chr1:37,663,328–37,663,865 | 106.7 kb | Distal (>10kb) Multiome | 44 | |
| chr1:37,690,078–37,690,919 | 133.6 kb | Distal (>10kb) Multiome | 679 | |
| chr1:37,691,459–37,692,843 | 135.4 kb | Distal (>10kb) Multiome | 781 | |
| chr1:37,752,766–37,753,277 | 196.1 kb | Distal (>10kb) Multiome | 223 | |
| chr1:37,793,768–37,794,528 | 237.2 kb | Distal (>10kb) Multiome | 567 | |
| chr1:37,807,583–37,809,057 | 251.3 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the DNALI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.