Enables heat shock protein binding activity; histone binding activity; and protein-folding chaperone binding activity. Involved in nucleosome assembly and positive regulation of ATP-dependent activity. Located in several cellular components, including cytosol; extracellular space; and nucleoplasm. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DNAJC9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,095,866–73,097,537 | 150.3 kb | Distal (>10kb) Multiome | 1042 | |
| chr10:73,167,766–73,168,681 | 79.1 kb | Distal (>10kb) Multiome | 879 | |
| chr10:73,246,675–73,247,516 | 59 bp | At TSS Multiome | 1023 | |
| chr10:73,252,167–73,253,067 | 5.4 kb | Proximal (<10kb) Multiome | 929 | |
| chr10:73,358,383–73,358,977 | 111.5 kb | Distal (>10kb) Multiome | 468 | |
| chr10:73,413,302–73,414,453 | 166.8 kb | Distal (>10kb) Multiome | 938 | |
| chr10:73,495,235–73,496,398 | 248.7 kb | Distal (>10kb) Multiome | 908 |
Genomic view of the DNAJC9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.