Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be located in cytoplasmic vesicle and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DNAJC27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:24,792,642–24,794,076 | 178.7 kb | Distal (>10kb) Multiome | 1010 | |
| chr2:24,821,671–24,822,465 | 149.7 kb | Distal (>10kb) Multiome | 172 | |
| chr2:24,827,474–24,828,282 | 144.2 kb | Distal (>10kb) Multiome | 460 | |
| chr2:24,919,504–24,920,824 | 51.7 kb | Distal (>10kb) Multiome | 431 | |
| chr2:24,971,247–24,972,384 | 2 bp | At TSS Multiome | 1032 | |
| chr2:24,972,610–24,972,808 | 655 bp | At TSS | 278 | |
| chr2:24,975,557–24,975,809 | 3.6 kb | Proximal (<10kb) | 179 | |
| chr2:25,041,314–25,043,455 | 70.1 kb | Distal (>10kb) Multiome | 743 | |
| chr2:25,131,383–25,132,709 | 160.4 kb | Distal (>10kb) Multiome HiCAR | 162 | |
| chr2:25,161,156–25,161,629 | 189.5 kb | Distal (>10kb) Multiome | 112 | |
| chr2:25,168,208–25,168,958 | 196.7 kb | Distal (>10kb) Multiome HiCAR | 225 | |
| chr2:25,215,506–25,216,577 | 244.2 kb | Distal (>10kb) Multiome | 303 | |
| chr2:25,228,812–25,229,707 | 257.1 kb | Distal (>10kb) Multiome | 332 | |
| chr2:25,250,582–25,253,280 | 280.5 kb | Distal (>10kb) Multiome | 927 | |
| chr2:25,256,230–25,257,422 | 284.8 kb | Distal (>10kb) Multiome | 198 | |
| chr2:25,259,433–25,260,091 | 287.9 kb | Distal (>10kb) Multiome | 160 |
Genomic view of the DNAJC27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.