Involved in cristae formation. Located in MICOS complex; SAM complex; and nuclear speck. Part of MIB complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DNAJC11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:6,418,998–6,420,339 | 282.0 kb | Distal (>10kb) Multiome | 335 | |
| chr1:6,440,165–6,441,114 | 261.2 kb | Distal (>10kb) Multiome | 215 | |
| chr1:6,446,981–6,449,427 | 254.7 kb | Distal (>10kb) Multiome | 665 | |
| chr1:6,455,053–6,455,773 | 246.5 kb | Distal (>10kb) Multiome | 105 | |
| chr1:6,470,716–6,471,189 | 230.9 kb | Distal (>10kb) Multiome | 148 | |
| chr1:6,471,308–6,471,972 | 230.2 kb | Distal (>10kb) Multiome | 192 | |
| chr1:6,486,194–6,486,953 | 215.2 kb | Distal (>10kb) Multiome | 416 | |
| chr1:6,489,772–6,491,050 | 211.7 kb | Distal (>10kb) Multiome | 676 | |
| chr1:6,497,162–6,497,841 | 204.3 kb | Distal (>10kb) Multiome | 324 | |
| chr1:6,554,053–6,554,774 | 147.3 kb | Distal (>10kb) Multiome | 897 | |
| chr1:6,579,406–6,580,453 | 121.9 kb | Distal (>10kb) Multiome | 684 | |
| chr1:6,601,460–6,604,144 | 98.9 kb | Distal (>10kb) Multiome | 1062 | |
| chr1:6,612,539–6,615,225 | 88.3 kb | Distal (>10kb) Multiome | 806 | |
| chr1:6,624,591–6,625,845 | 76.6 kb | Distal (>10kb) Multiome | 730 | |
| chr1:6,701,304–6,702,223 | 61 bp | At TSS Multiome | 1025 | |
| chr1:6,784,205–6,786,365 | 83.3 kb | Distal (>10kb) Multiome | 950 | |
| chr1:6,961,705–6,964,510 | 261.1 kb | Distal (>10kb) Multiome | 485 |
Genomic view of the DNAJC11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.