DNAJB2
DnaJ heat shock protein family (Hsp40) member B2 | CMT2T, HSPF3, HSJ1

This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

Member of: DE-4 DE-4.17 Developmental clusters: GC7
Biological processes 53 terms
ATPase activator activity (GO:0001671)ATPase activator activity (GO:0001671)ERAD pathway (GO:0036503)Hsp70 protein binding (GO:0030544)Hsp70 protein binding (GO:0030544)Hsp70 protein binding (GO:0030544)Hsp70 protein binding (GO:0030544)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic side of endoplasmic reticulum membrane (GO:0098554)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)inclusion body (GO:0016234)negative regulation of cell growth (GO:0030308)negative regulation of cell population proliferation (GO:0008285)negative regulation of inclusion body assembly (GO:0090084)negative regulation of inclusion body assembly (GO:0090084)negative regulation of inclusion body assembly (GO:0090084)negative regulation of protein binding (GO:0032091)negative regulation of protein deubiquitination (GO:0090086)neuron cellular homeostasis (GO:0070050)nuclear membrane (GO:0031965)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)polyubiquitin modification-dependent protein binding (GO:0031593)positive regulation of ATP-dependent activity (GO:0032781)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of protein ubiquitination (GO:0031398)proteasome binding (GO:0070628)proteasome complex (GO:0000502)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein folding (GO:0006457)protein refolding (GO:0042026)protein refolding (GO:0042026)protein serine/threonine kinase binding (GO:0120283)protein-folding chaperone binding (GO:0051087)protein-folding chaperone binding (GO:0051087)regulation of protein folding (GO:1903332)regulation of protein localization (GO:0032880)regulation of protein ubiquitination (GO:0031396)response to unfolded protein (GO:0006986)ubiquitin binding (GO:0043130)ubiquitin protein ligase binding (GO:0031625)ubiquitin-modified protein reader activity (GO:0140036)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)
Expression (TPM)
DNAJB2 — as a Regulated Gene

TFs regulating DNAJB2 0 TFs

Transcription factors with Perturb-seq knockdown data for DNAJB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to DNAJB2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:218,979,814–218,980,492 299.2 kb Distal (>10kb) Multiome 499
chr2:218,984,382–218,985,013 294.7 kb Distal (>10kb) Multiome 126
chr2:218,992,930–218,994,312 285.7 kb Distal (>10kb) Multiome 265
chr2:218,995,885–218,998,018 283.1 kb Distal (>10kb) Multiome 534
chr2:218,998,611–219,003,562 277.3 kb Distal (>10kb) Multiome 941
chr2:219,057,853–219,058,462 221.2 kb Distal (>10kb) Multiome 469
chr2:219,060,260–219,061,256 218.4 kb Distal (>10kb) Multiome 240
chr2:219,159,910–219,161,297 118.8 kb Distal (>10kb) Multiome 901
chr2:219,176,168–219,177,450 102.5 kb Distal (>10kb) Multiome 999
chr2:219,177,596–219,178,930 101.1 kb Distal (>10kb) Multiome 930
chr2:219,206,194–219,207,456 72.5 kb Distal (>10kb) Multiome 861
chr2:219,217,908–219,219,751 60.4 kb Distal (>10kb) Multiome 1058
chr2:219,228,940–219,230,470 49.7 kb Distal (>10kb) Multiome 914
chr2:219,245,074–219,245,804 33.9 kb Distal (>10kb) Multiome 891
chr2:219,252,908–219,254,656 25.3 kb Distal (>10kb) Multiome 808
chr2:219,274,694–219,274,892 4.4 kb Proximal (<10kb) 182
chr2:219,277,516–219,280,537 29 bp At TSS Multiome 1073
chr2:219,285,909–219,286,354 6.6 kb Proximal (<10kb) 131
chr2:219,294,524–219,295,391 15.6 kb Distal (>10kb) Multiome 892
chr2:219,308,224–219,309,089 29.0 kb Distal (>10kb) Multiome 742
chr2:219,386,994–219,389,117 108.9 kb Distal (>10kb) Multiome 911
chr2:219,402,761–219,403,203 123.7 kb Distal (>10kb) Multiome 234
chr2:219,418,154–219,419,089 139.4 kb Distal (>10kb) Multiome 147
chr2:219,433,920–219,435,459 154.8 kb Distal (>10kb) Multiome 315
chr2:219,441,439–219,442,557 162.6 kb Distal (>10kb) Multiome 338
chr2:219,447,946–219,449,531 169.5 kb Distal (>10kb) Multiome 244
chr2:219,476,330–219,477,528 197.4 kb Distal (>10kb) Multiome 373
chr2:219,484,139–219,485,299 205.6 kb Distal (>10kb) Multiome 146
chr2:219,497,658–219,499,313 219.4 kb Distal (>10kb) Multiome 907
chr2:219,506,707–219,507,641 227.8 kb Distal (>10kb) Multiome 205
chr2:219,509,036–219,510,612 230.8 kb Distal (>10kb) Multiome 614
chr2:219,521,083–219,521,760 242.1 kb Distal (>10kb) Multiome 325
chr2:219,522,621–219,523,337 243.7 kb Distal (>10kb) Multiome 201
chr2:219,525,558–219,526,393 246.7 kb Distal (>10kb) Multiome 321
chr2:219,530,046–219,530,655 251.0 kb Distal (>10kb) Multiome 480
chr2:219,541,583–219,542,284 262.5 kb Distal (>10kb) Multiome 764
chr2:219,542,939–219,544,543 264.6 kb Distal (>10kb) Multiome 981
chr2:219,551,360–219,553,449 273.2 kb Distal (>10kb) Multiome 785
chr2:219,570,096–219,572,421 292.3 kb Distal (>10kb) Multiome 948

Genome Browser

Genomic view of the DNAJB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:218,969,814 – 219,582,421
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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