Enables Hsp70 protein binding activity. Involved in chaperone cofactor-dependent protein refolding and protein-containing complex assembly. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for DNAJB14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJB14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJB14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:99,893,878–99,895,182 | 52.1 kb | Distal (>10kb) Multiome | 653 | |
| chr4:99,945,763–99,947,717 | 76 bp | At TSS Multiome | 880 | |
| chr4:99,948,810–99,951,411 | 3.9 kb | Proximal (<10kb) Multiome | 994 | |
| chr4:100,093,092–100,094,001 | 147.0 kb | Distal (>10kb) Multiome | 358 | |
| chr4:100,189,399–100,191,698 | 243.8 kb | Distal (>10kb) Multiome | 477 |
Genomic view of the DNAJB14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.