DNAJA3

DnaJ heat shock protein family (Hsp40) member A3 | Tid1-L, Tid1-S, hTid-1, TID1

This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Member of: DE-6 Developmental clusters: GC3

Biological processes 54 terms

ATP binding (GO:0005524)ATP-dependent protein folding chaperone (GO:0140662)DNA-binding transcription factor binding (GO:0140297)Hsp70 protein binding (GO:0030544)IkappaB kinase complex binding (GO:0106137)NF-kappaB binding (GO:0051059)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)actin filament (GO:0005884)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytosol (GO:0005829)cytosol (GO:0005829)heat shock protein binding (GO:0031072)immune system process (GO:0002376)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial nucleoid (GO:0042645)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)negative regulation of apoptotic process (GO:0043066)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of cell population proliferation (GO:0008285)negative regulation of programmed cell death (GO:0043069)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of type II interferon-mediated signaling pathway (GO:0060336)neuromuscular junction (GO:0031594)neuromuscular junction development (GO:0007528)neuromuscular junction development (GO:0007528)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of apoptotic process (GO:0043065)positive regulation of protein ubiquitination (GO:0031398)postsynaptic membrane (GO:0045211)postsynaptic membrane (GO:0045211)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein stabilization (GO:0050821)protein-containing complex binding (GO:0044877)regulation of cell population proliferation (GO:0042127)regulation of immune system process (GO:0002682)response to heat (GO:0009408)response to stress (GO:0006950)response to type II interferon (GO:0034341)signaling receptor binding (GO:0005102)skeletal muscle acetylcholine-gated channel clustering (GO:0071340)type II interferon receptor binding (GO:0005133)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating DNAJA3 0 TFs

Transcription factors with Perturb-seq knockdown data for DNAJA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DNAJA3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:4,183,149–4,184,737	241.9 kb	Distal (>10kb) Multiome	944
chr16:4,244,460–4,244,980	181.2 kb	Distal (>10kb) Multiome	290
chr16:4,253,312–4,254,436	171.9 kb	Distal (>10kb) Multiome	960
chr16:4,263,483–4,264,402	162.1 kb	Distal (>10kb) Multiome	258
chr16:4,271,070–4,274,312	151.8 kb	Distal (>10kb) Multiome	1130
chr16:4,293,681–4,294,322	131.9 kb	Distal (>10kb) Multiome	385
chr16:4,307,236–4,308,275	118.0 kb	Distal (>10kb) Multiome	635
chr16:4,309,629–4,310,195	115.9 kb	Distal (>10kb) Multiome	351
chr16:4,315,041–4,316,747	110.1 kb	Distal (>10kb) Multiome	520
chr16:4,327,446–4,328,634	97.6 kb	Distal (>10kb) Multiome	495
chr16:4,350,579–4,351,773	74.5 kb	Distal (>10kb) Multiome	674
chr16:4,371,473–4,372,791	54.0 kb	Distal (>10kb) Multiome	617
chr16:4,402,485–4,403,104	23.1 kb	Distal (>10kb) Multiome	450
chr16:4,415,818–4,417,201	9.2 kb	Proximal (<10kb) Multiome	681
chr16:4,425,392–4,426,322	146 bp	At TSS Multiome	881
chr16:4,474,111–4,474,929	48.7 kb	Distal (>10kb) Multiome	626
chr16:4,476,027–4,477,237	50.5 kb	Distal (>10kb) Multiome	841
chr16:4,537,639–4,538,998	112.8 kb	Distal (>10kb) Multiome	1087
chr16:4,585,331–4,585,992	159.8 kb	Distal (>10kb) Multiome	223
chr16:4,613,912–4,617,164	189.0 kb	Distal (>10kb) Multiome	1079
chr16:4,624,301–4,625,703	198.8 kb	Distal (>10kb) Multiome	866
chr16:4,693,016–4,694,663	267.7 kb	Distal (>10kb) Multiome	730

Genome Browser

Genomic view of the DNAJA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.