Transcription factors with Perturb-seq knockdown data for DMXL1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMXL1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMXL1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:118,951,671–118,953,627 | 118.5 kb | Distal (>10kb) Multiome | 243 | |
| chr5:118,987,706–118,989,045 | 82.4 kb | Distal (>10kb) Multiome | 941 | |
| chr5:119,070,182–119,071,897 | 166 bp | At TSS Multiome | 975 | |
| chr5:119,079,337–119,079,900 | 8.4 kb | Proximal (<10kb) | 164 | |
| chr5:119,255,677–119,256,535 | 185.2 kb | Distal (>10kb) Multiome | 184 | |
| chr5:119,267,854–119,269,617 | 197.7 kb | Distal (>10kb) Multiome | 918 | |
| chr5:119,316,153–119,316,863 | 245.6 kb | Distal (>10kb) Multiome | 112 | |
| chr5:119,354,971–119,356,548 | 285.0 kb | Distal (>10kb) Multiome | 521 |
Genomic view of the DMXL1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.