This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for DMKN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMKN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMKN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,247,580–35,249,688 | 261.7 kb | Distal (>10kb) Multiome | 1088 | |
| chr19:35,266,852–35,270,128 | 240.8 kb | Distal (>10kb) Multiome | 869 | |
| chr19:35,471,034–35,471,539 | 39.2 kb | Distal (>10kb) Multiome | 15 | |
| chr19:35,502,859–35,503,105 | 7.1 kb | Proximal (<10kb) | 25 | |
| chr19:35,509,319–35,509,517 | 731 bp | At TSS | 261 | |
| chr19:35,509,786–35,510,900 | 21 bp | At TSS Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 35.2 kb | Distal (>10kb) Multiome | 879 | |
| chr19:35,557,343–35,558,684 | 47.6 kb | Distal (>10kb) Multiome | 452 | |
| chr19:35,612,546–35,613,176 | 102.2 kb | Distal (>10kb) Multiome | 778 | |
| chr19:35,628,465–35,629,474 | 118.4 kb | Distal (>10kb) Multiome | 889 | |
| chr19:35,641,602–35,642,192 | 131.3 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,643,064–35,645,730 | 133.1 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:35,648,040–35,648,575 | 137.7 kb | Distal (>10kb) Multiome | 599 | |
| chr19:35,673,179–35,673,643 | 162.9 kb | Distal (>10kb) Multiome | 311 | |
| chr19:35,702,152–35,702,985 | 192.0 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 207.3 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 230.3 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 234.8 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 238.0 kb | Distal (>10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 247.6 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 257.5 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 265.0 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 274.3 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the DMKN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.