This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for DMC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:38,052,312–38,052,803 | 517.7 kb | Distal (>10kb) Multiome HiCAR | 529 | |
| chr22:38,057,008–38,057,702 | 512.9 kb | Distal (>10kb) Multiome HiCAR | 656 | |
| chr22:38,181,365–38,182,291 | 388.3 kb | Distal (>10kb) Multiome HiCAR | 676 | |
| chr22:38,272,379–38,273,237 | 297.2 kb | Distal (>10kb) Multiome | 526 | |
| chr22:38,317,171–38,317,940 | 252.8 kb | Distal (>10kb) Multiome | 524 | |
| chr22:38,319,024–38,319,874 | 250.6 kb | Distal (>10kb) Multiome | 181 | |
| chr22:38,335,940–38,336,726 | 233.9 kb | Distal (>10kb) Multiome | 297 | |
| chr22:38,353,217–38,354,166 | 216.7 kb | Distal (>10kb) Multiome | 404 | |
| chr22:38,397,757–38,399,352 | 171.2 kb | Distal (>10kb) Multiome | 345 | |
| chr22:38,455,555–38,456,345 | 114.1 kb | Distal (>10kb) Multiome | 403 | |
| chr22:38,461,291–38,461,848 | 108.5 kb | Distal (>10kb) Multiome | 595 | |
| chr22:38,505,466–38,506,961 | 63.7 kb | Distal (>10kb) Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 175 bp | At TSS Multiome | 559 | |
| chr22:38,655,982–38,657,104 | 86.3 kb | Distal (>10kb) Multiome | 698 | |
| chr22:38,681,730–38,682,262 | 111.7 kb | Distal (>10kb) Multiome | 947 | |
| chr22:38,700,377–38,701,744 | 130.8 kb | Distal (>10kb) Multiome | 916 | |
| chr22:38,705,151–38,706,595 | 135.5 kb | Distal (>10kb) Multiome | 821 | |
| chr22:38,755,428–38,756,383 | 185.9 kb | Distal (>10kb) Multiome | 770 | |
| chr22:38,793,674–38,794,378 | 224.0 kb | Distal (>10kb) Multiome | 484 | |
| chr22:38,843,207–38,844,443 | 273.6 kb | Distal (>10kb) Multiome | 585 | |
| chr22:38,866,394–38,866,832 | 296.4 kb | Distal (>10kb) Multiome | 76 |
Genomic view of the DMC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.