DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DLL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:169,789,764–169,790,892 | 516.2 kb | Distal (>10kb) Multiome HiCAR | 772 | |
| chr6:170,006,902–170,008,105 | 299.2 kb | Distal (>10kb) Multiome | 196 | |
| chr6:170,289,086–170,292,550 | 15.6 kb | Distal (>10kb) Multiome | 490 | |
| chr6:170,295,396–170,297,381 | 10.6 kb | Distal (>10kb) Multiome | 655 | |
| chr6:170,306,110–170,307,169 | 71 bp | At TSS Multiome | 935 | |
| chr6:170,552,943–170,554,837 | 247.8 kb | Distal (>10kb) Multiome | 1097 | |
| chr6:170,584,110–170,585,439 | 278.1 kb | Distal (>10kb) Multiome | 965 |
Genomic view of the DLL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.