This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for DLG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:70,289,676–70,290,592 | 162.2 kb | Distal (>10kb) Multiome | 481 | |
| chrX:70,433,669–70,435,047 | 17.8 kb | Distal (>10kb) Multiome | 638 | |
| chrX:70,452,116–70,452,807 | 74 bp | At TSS Multiome | 254 | |
| chrX:70,454,439–70,455,911 | 2.6 kb | Proximal (<10kb) Multiome | 546 | |
| chrX:70,508,261–70,509,156 | 56.3 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the DLG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.