Transcription factors with Perturb-seq knockdown data for DLG2-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLG2-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLG2-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:83,443,851–83,444,454 | 201.7 kb | Distal (>10kb) Multiome | 56 | |
| chr11:83,724,266–83,725,551 | 79.3 kb | Distal (>10kb) Multiome | 319 | |
| chr11:83,836,349–83,837,522 | 191.1 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the DLG2-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.