This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
Transcription factors with Perturb-seq knockdown data for DKK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DKK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DKK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:52,308,085–52,309,123 | 6.1 kb | Proximal (<10kb) Multiome | 588 | |
| chr10:52,312,997–52,315,411 | 355 bp | At TSS Multiome | 866 | |
| chr10:52,318,201–52,318,414 | 3.9 kb | Proximal (<10kb) | 103 | |
| chr10:52,322,339–52,322,682 | 8.1 kb | Proximal (<10kb) | 9 | |
| chr10:52,452,308–52,453,450 | 138.1 kb | Distal (>10kb) Multiome HiCAR | 406 |
Genomic view of the DKK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.